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Abstract #1708

Four-Dimensional Spectral Spatial PH Mapping of Mouse Tumour Using Continuous Wave-Electron Paramagnetic Resonance Imaging (CW-EPRI) and PH Sensitive Imidazoline Nitroxide

Jonathan Goodwin1, Shunichi Koda1, Masashi Ohfuchi1, Anna Pawlak1, Hironobu Yasui2, Valery Khramstov3, Hiroshi Hirata1

1Hokkaido University, Sapporo, Hokkaido, Japan; 2Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; 3Ohio State University

In this work we assess the viability of pH sensitive imidazoline nitroxide for in-vivo pH mapping of mouse tumour using continuous wave electron paramagnetic resonance imaging (CW-EPR) to perform four dimensional spectral-spatial imaging. Comparison of pH in tumour model mouse leg was found to be reduced compared control mouse leg. Co-registration with 7T MRI demonstrated anatomical distribution of acquired pH map obtained from tumour model mouse. Successful demonstration of the technique in a larger population will allow further exploration of the relationship between pHe in tumour, and how the relationship changes in response to radiotherapy with and without radio-sensitizing drugs.

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Keywords

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