Myocardial Pyruvate Dehydrogenase Flux in Long-Chain Acyl-CoA Dehydrogenase Knock-Out Mice

Keywords

academic access achieved acid addition affected analyzed anesthetized animals assess assigned attempt bicarb bicarbonate biomedical built cardiac carefully catheter chain chemical chest citric coil compensate compensatory complex condition conditions constant contribution control controls cycle decreased defect demonstrating described determines diastolic diet diseases disorders dissolved domain energy enzymes examination excitation extent fasted fasting fatty fellowship findings fitting flexibility flux foundation function genetic genotype glucose heart home homeostasis hours housed hypothesized important in vivo incorporation injected injection input interestingly intermediates investigate kinetic kingdom knock label labeled laboratory localization long maintain male medical metabolic metabolism mice minute model mouse much myocardial myocardium ongoing oxford oxidation pathways patients peaks performance plays pool positioned positioning presence previously pulse quantifications received reduced reductions relatively remained resolution revealed rodent role sander scanner separate short software solution spectra spectrum substantiate substrate sufficiently suggests summed supine supported surface systolic tail technology temporal term towards triggered type unable utilization vein weeks wild yielding