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Abstract #1665

Parallel Spiral Chemical Shift Imaging for Metabolic Imaging with Hyperpolarised 13C

Markus Durst1, 2, Rolf F. Schulte2, Franz Schilling1, Eliane Weidl3, Oleksandr Khegai2, 4, Martin A. Janich, 24, Jonathan I. Sperl2, Ulrich Koellisch1, Florian Wiesinger2, Markus Schwaiger3, Axel Haase1

1IMETUM, Technische Universitt Mnchen, Munich, Bavaria, Germany; 2GE Global Research, Munich, Bavaria, Germany; 3Department for Nuclear Medicine, Technische Universitt Mnchen, Munich, Bavaria, Germany; 4Department of Chemistry, Technische Universitt Mnchen, Munich, Bavaria, Germany

Imaging hyperpolarised compounds requires rapid acquisition methods due to irreversible T1 decay of the magnetisation. In this work, parallel imaging is used to improve the spatial resolution and spectral width of spiral chemical shift images of healthy rats in-vivo after injection of hyperpolarised [1-13C]pyruvate.

Keywords

acquisition acquisitions adapted addition agreement aliasing almost anatomical application artifacts averaging become beneficial biomedical calibration channel chemical chemistry coil coils collected combination complete completely compounds cover dataset decaying density depending designed desired determine determined distribution durst efficient eliminates encode entire excitation excitations flexible flow fold fully global good gradient gradients grant healthy ideal identical implementation implemented improve in vivo inhomogeneous injection instruments interleave interleaved interleaves interpolation invaluable inversion irreversibly kernel kidney kidneys least length liver loose male martin materials matrix mayer medicine metabolic metabolites motion narrow noise nominal nuclear optimal outer oxford parallel partially particularly press principle profiles proton pulse rapid rapidly rats receiver reconstruct reconstructed reconstruction recorded reduce reducing reeder requirements resolution rewinder rewinding rotated rotations sampled sampling scanner schilling sensitivity separation several shot since slices solution space spatial spatially specifically spectral spectrum spiral spirals spirit spoiled squares step steps subsequently sufficient support tail temporally tool trajectory vein width widths