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Abstract #1629

Multifunctional Anionic Nanoparticles for the Targeted Delivery of Therapeutic Agents to the Brain for the Treatment of Dementias

Gavin D. Kenny1, 2, Alison Bienemann3, Katharina Welser4, Frederick Campbell4, Aristides D. Tagalakis1, Mauro Botta5, Alethea B. Tabor4, Ed White3, Mark F. Lythgoe2, Stephen L. Hart1

1Molecular Immunology Unit ICH, UCL, London, United Kingdom; 2Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom; 3Functional Neurosurgery Group, University of Bristol, Bristol, United Kingdom; 4Department of Chemistry, UCL, London, United Kingdom; 5Dipartimento di Scienze dell 'Ambiente e della Vita, Universit del Piemonte Orientale "Amedeo Avogadro", Alessandria, Italy

Genetic therapies offer great promise for the development of new therapeutics in the CNS. One of the major obstacles to overcome is the inability to effectively bypass the BBB and deliver the therapeutic nucleic acids to the affected region. Nanoparticles are extensively used as delivery vectors for genes due to their biocompatibility and the protection they afford the gene and if administered using convection enhanced delivery the BBB can be circumvented. Here we have investigated the use of anionic nanoparticles, that are MR sensitive, contain labels for fluorescence microscopy/histology, in combination with a targeting peptide to mediate the functional delivery.

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Keywords

able acid acids administration advanced affected afford aged allow allows amino animals anionic anionics articles barrier biomedical blood brain brains bristol bypass camera cation cationic cell central charge clearly clinic coil condense contain containing convection copy corpus corroborated deliver delivered delivery dell dementias determine digital disorders distribution dope drilled ease enhanced ermined ever expression film fixation fixed fluorescence focused formation formula formulation formulations frame functional fused gadolinium gene genetic gradient great hand hart histology holes hull hydration hype in vivo inability incubated infusion injection invasiveness killed kingdom labels lipid major mark meas measured mediate mediated medical mine mixing mixture molecular monitoring need novel nucleic obstacles offer outer particle particles particular peptide placed potential precision prepared produced promise protection pump rapid rats real reducing regulation required resolution room scanner sectioned silica site situ stereo strategies system tabor target targeted targeting terminal therapeutics therapies treatment treatments unit universal visage vita volume volumes white wide withdrawn