Meeting Banner
Abstract #1623

Magnetic Resonance Molecular Imaging of Atherosclerotic Plaque in an Atherosclerosis Mouse Model

MAGNA25Xueming Wu1, Niranjan Balu2, Wen Li1, Yong Chen1, Xin Yu1, Chun Yuan2, Zheng-Rong Lu1

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Department of Radiology, University of Washington, Seatle, WA, United States

This study designed, synthesized and evaluated a peptide-based low molecular weight MRI contrast agent specific to clotted plasma proteins for molecular imaging of atherosclerotic plaques with MRI. The atherosclerotic plaque imaging effectiveness of the targeted agent was demonstrated by using an atherosclerotic apolipoprotein Edeficient mouse model. Our preliminary results demonstrate that the newly developed targeted MRI contrast agent is promising for noninvasive assessment of plaque progression in an atherosclerotic mouse model.

Abstract PDF

Keywords

able accurate administered agent agents amount animal animals aorta aortic arch assessment assigned atherosclerosis axial bind binding binds biomedical black blood brown cancer catheter chem clinical clinically clotting complexes confirmed conjugating contrast control deficient deliver designed detection developed diagnosis diet diseases dose early effective efficacy engineering enhanced enhancement evaluate experimental fibrin fluorescence formed in vivo injected injection labeled lasted life limited little materials measured mice minutes modality model molecular mouse much natl need newly noise noninvasive onset parker peptide period peters plaque plaques plasma powerful preliminary progression promising proteins radiology randomly replacing reserve safe scanner scrambled sensitivity specifically specificity spin strong stronger studies sufficient suitable synthesized tail target targeted targeting threatening tissues vein verified wall week weeks western whole yang yuan