T1 Modulation of CEST in a Eu(III)-DOTA-Tetraamide-Bis(Nitroxyl) Complex

Keywords

acid addition advanced agent agents alternative anticipated appended applied arms around axial biological blue bound bulk butyl cage certain characteristic chem chemical collected coming complex complexes conditions consequently containing contrast coordinating coordination covalently deactivated dean decreases derivatives design designed determined diamagnetic distinct efficiency efficient electronic equivalents ester even exchange exchanging exhibits exists experimental fast free fully geometry highly hydrolysis illustrated implies includes indicates inefficient influence intensity inversion isomer lanthanide largely ligand longer longitudinal magnetization magnitude many mechanism media medical metal modulated modulation moieties molecule much near negligible paramagnetic peak pendant phantom phantoms platform pool pools preferred preliminary presence probes properties proton protons pulse quenched quite radical radicals rationally reaction recorded recovers recovery reduced reducing reduction report responsive ring sample samples saturated saturation scaffold selective sensitive sherry since slow southwestern spectra spectroscopy spectrum spin spins square substantial summary synthesized system tempo though traditional transfer turned units water yuan