Meeting Banner
Abstract #1616

Gadolinium- And Dysprosium-Encapsulated Single-Walled Ultra-Short Carbon Nanotubes as Intracellular Agents for High Field MR Microscopy at 11.75 and 21.1 T

Jens T. Rosenberg1, 2, Micheal L. Matson3, 4, Brandon T. Cisneros3, Michelle Sokoll2, Fabian Calixo-Bejarano1, Lon J. Wilson3, Samuel Colles Grant1, 2

1Center for Interdisciplinary Magnetic Resonance, The National High Magnetic Field Laboratory, Tallahassee, FL, United States; 2Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 3Department of Chemistry and The Smalley Institute for Nanoscale Science and Technology, Rice University, Houston, TX, United States; 4Natural Sciences, University of Houston-Downtown, Houston, TX, United States

Ultra-short, singled walled carbon nanotubes (US-tubes) that encapsulate gadolinium (Gd) have shown MRI cell tracking capabilities. Their biocompatibility together with a hollow interior and potentially beneficial water access are factors of interest especially at high magnetic fields. In this study, Gd-doped US-tubes are compared to a high field optimized, dysprosium (Dy) variant. Results suggest that doped US-tubes in solution follow theoretical field-dependent changes in relaxation for the two lanthanides. Once incorporated into cells, T1 contrast is quenched while T2 and T2* contrast dominates. Dy-doped US-tubes have overall shorter transverse relaxation times and compares favorably to other Dy-based agents.

Abstract PDF

Keywords

access addition additional adherent affected agents appears applications aqueous association bath benefits biomedical capability carbon cell cells centrifuged chem chemical chemistry collected college comparing concentrations confinement conjugated consistent contrast controls cylindrically decrease decreased deionized delivery dialyzed diluted displays dominant dominates dominating doped downtown drug dysprosium effective either empty encapsulate encapsulated engineering equipped evaluates excess exchange expected exposed favorable favorably field fields final foundation funding gadolinium gained gradient grant hand harvest heart homogenized immersing incorporated institute interdisciplinary interior internalized intracellular ionic isotropic label laboratory lanthanide larger macrophages made magnets mechanism mechanisms media membranes microscopy mixed much national opposite outline overall particular previously probe program quenching quite recalled recent reduction remove resolution respectively rice running serial shaped short shorter slice slight solution spin still stock strength successfully supernatant surface surfactant suspension synthesized table tang technology theoretical together trans trends tube tubes ultra unlabeled user varied vertical volume walled washed washings water woods years