Meeting Banner
Abstract #1613

Synthesis and Evaluation of a Biodegradable Macromolecular Contrast Agent Containing Macrocyclic Gd(III) Chelates for Cancer MRI

Zhen Ye1, 2, Xueming Wu2, Zheng-Rong Lu2

1Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, United States; 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

A neutral biodegradable polymeric MRI contrast agent containing macrocyclic Gd chelates, GOLS, were synthesized and evaluated for clinical contrast-enhanced MR imaging. The agent had higher relaxivity than clinical agents, and can be readily degraded. Kinetic stability study showed that this agent had significantly higher stability against transmetallation than polymer based on linear chelates. The contrast-enhancing efficacy of GOLS was evaluated on mice bearing orthotopic 4T1 breast tumor. Significantly higher tumor enhancement was generated by GOLS than clinical agents. This new agent is of great potential as a safe and effective contrast agent in contrast enhanced MRI.

Abstract PDF Poster PDF

Keywords

acid agent agents alleviate animal axial bearing better biodegradability biodegradable biomedical breast cancer caravan characterization chelation chemical chemistry chromatography circle city clinical complex complexes concentration concerns containing content contrast control copolymer copolymers decrease degraded derivative desirable detected determined develop developed distribution dose effective efficacy endogenous engineering enhanced enhancement evaluated evaluation exclusion excreted excretion facilitate filtration free generated generation gradual in vivo incubating incubation injection investigated ions journal kinetic kinetics lake ligand linear little macromolecular macromolecules materials metal mice minimal minutes model molecular mouse much neutral paired percentage pharmaceutical pharmaceutics physiological plasma polymers poor post preliminary prolonged promising properties raised readily release renal reported reserve respectively retention safe safety salt scanner significantly slow spin square stability statistical structure student studied studies synthesis synthesized tailed tissue tissues tumor western