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Abstract #1610

Intrabiliary MRI-Monitored Local Delivery of Motexafin Gadolinium

Feng Zhang1, Yanfeng Meng1, Stephanie Soriano1, Patrick Willis1, David Glickerman1, Xiaoming Yang1

1Radiology, University of Washington, Seattle, WA, United States

This study was to develop a new technique of intrabiliary MRI-guided local agent delivery. We validated the feasibility of using MR to monitor, in vivo, intrabiliary delivery of MGd into the pig common bile duct walls of 6 pigs, which was confirmed by subsequent MRI-histology correlation. This new technique may open new revenues for MR-guided intrabiliary local delivery of therapeutics, such as genes and drugs, to treat malignant pancreatobiliary diseases.

Keywords

abdominal access advanced agent agents array arrow arrows autofluorescence avenues background balloon bile biliary blue cancers catheter clock closure coil common confirm confirmed confocal considered contrast contributors control correlation created defect delivery demonstrating detect develop deviation dose duct duodenum effectively either emission emitting enhanced examination examined expose exposed feasibility field findings fluorescence fluorescent gadolinium gallbladder gated generated harvested hepatic histological immediately in vivo inch incision indicate indicates infiltration inflated infused infusion insertion insets insufficient intensities introducer laser light living local long magnifications malignancies malignancy manage markers matrix measured metal microscopic microscopy mixture monitor monitored noise obstruction obstructive open outlining overcome paired penetrated penetration pigs placed poor post problem procedure prognosis radiology represent respiration saline segment sets short slice slides stained statistically student successful summarizes suppressed surface surgery taken therapeutic tissues torso transferred tumor turbo wall walls yang