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Abstract #1598

Retrospective R1 Atlas Mapping of Brain Infusions

Do P.M. Tromp1, Marina E. Emborg1, Samuel A. Hurley1, Nagesh Adluru1, Martin L. Brady2, Raghu Raghavan2, Ken Kubota3, Andrew L. Alexander1

1University of Wisconsin, Madison, WI, United States; 2Therataxis, Baltimore, MD, United States; 3Kinetics Foundation, Los Altos, CA, United States

New treatments of brain diseases like Parkinsons disease and brain tumors are focusing on direct and local delivery of therapeutics in the brain. Convection-enhanced delivery (CED) has been proposed to increase the distribution and dose of therapeutic agents in a target area beyond simple diffusion. In this project we developed an image analysis framework to retrospectively generate a normalized statistical atlas of infusion studies, which will facilitate the investigation of how different infusion factors influence the treatment outcome.

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Keywords

agent agents altos anatomical anatomicals animals anterior ants apart applied applying approval atlas beyond body borders brain buffered care catheter characterize coil collected compatible computed concentration consistency convection critical delivering delivery design developed deviation diameter diffusion direct directly disease diseases displays distribution dorsal dose effective enable enhanced enhancing estimation experimental extraction facilitate federal finally focusing frame framework fused future gadolinium geometry gradient guided head important in vivo include influence infusion infusions intended intervals investigation kinetics like local macaque manual mapping maps martin matrix minimizing minute minutes model monkey monkeys necessary normalization normalized original outcomes outline outside overview part patterns phosphate pipeline placed position post prior processing properties proposed quality rage registered registration related resolution resolved retrospective retrospectively rigid roughly schematic separately silica skull slice sliding smith solution space spatial sphinx spoiled statistical stripped structural studies successful sufficient surface target targeted targeting template therapeutic therapeutics tissue tool tracer treat treatment tromp tumors versions warped