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Abstract #1595

Imaging Tasks Useful in Convection-Enhanced Drug Delivery in the Brain: Depicting Distal Cerebral Vasculature

Miles Olsen1, Benjamin Grabow1, Ethan Brodsky1, Karl Sillay1, Andy Alexander1, Labonny Biswas2, Roey Flor2, Perry Radau2, Graham Wright2, Walter Block1

1University of Wisconsin - Madison, Madison, WI, United States; 2Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

Improving the understanding of convection-enhanced delivery (CED) of drugs requires easy to use software for targeting, monitoring, and evaluating the treatment zone. We concentrate here on imaging and visualizing distal cerebral vasculature that could present unwanted escape routes during possible CED treatment for Parkinsons disease in the putamens. An imaging protocol is presented that surpasses conventional Time of Flight in visualizing the perforating arteries in the putamen, vessels too small to be of interest in clinical imaging today. An extensible open-source software platform is modified to show both vascular and T1-weighted image volumes for later catheter alignment in CED procedures.

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Keywords

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