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Abstract #1539

Dose-Dependent Effects of Bevacizumab in Human HCC Xenografts

Septian Hartono1, 2, Tong San Koh, 12, Quan Sing Ng2, Richard Ong2, Hung The Huynh2, Sidney Yu3, Sotirios Bisdas4, Laurent Martarello5, Choon Hua Thng2

1Nanyang Technological University, Singapore, Singapore; 2National Cancer Centre, Singapore, Singapore; 3Singapore General Hospital, Singapore; 4Eberhard Karls University, Tbingen, Germany; 5F. Hoffmann-La Roche, Switzerland

We aim to determine if DCE MRI is a sensitive enough technique to detect changes in fractional intravascular volume and blood flow after administration of a single dose of bevacizumab. The results showed that the effects of bevacizumab are dose-related. A more gradual drop of blood volume was observed in group treated with bevacizumab 1mg/kg. On the other hand, a steep drop of blood volume was observed in group treated with bevacizumab 10mg/kg. The results suggested potential of DCE MRI as a sensitive biomarker of microvascular density.

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