Meeting Banner
Abstract #1522

Mapping of Oxygen by Imaging Lipids Relaxation Enhancement (MOBILE) in Experimental Tumor Models: Comparison with R2*, R1 H2O, and OxyLite Fiber Optic Probes.

Benedicte F. Jordan1, Julie Magat1, Elif Ozel1, Florence Colliez1, Anne-Catherine Fruytier1, Valerie Marchand1, Lionel Mignion1, Caroline Bouzin2, Olivier Feron2, Bernard Gallez1

1Biomedical Magnetic Resonance Group, Universit Catholique de Louvain, Brussels, Belgium; 2Pole of Pharmacotherapy, Universit Catholique de Louvain, Brussels, Belgium

There is a critical need for methods able to monitor dynamically and noninvasively tumor oxygenation. The purpose of the current work was to compare the MOBILE technique, a method developed to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids by exploiting the higher solubility property of oxygen in lipids than in water, with R2*, R1 H2O, and simultaneous quantitative oxygen measurements using fluorescence quenching fiber optic probes. Changes in tumor oxygenation were induced by an hyperoxic breathing challenge in order to determine correlations between the response assessed using each technique.

Abstract PDF Poster PDF

Keywords

able acknowledged acquisition acts addition afforded agent allowing anesthetized assess assessed assessing benefit best biomedical bottoms breathing cells challenge coil compartments compatible complementary conditions contrast correlation correlations critical determine developed diameter dissolved dynamically echoes enhancement evaluated exclusion expected experiment experimental exploiting fast fiber fluorescence frequency generated gradient hertz human hypoxia implanted important improved improving indeed individualize induced inner inserted keep lancet lead linear lipid lipids localized major majority mammary mapping maps material matrix measured mice might mind mobile mode model models monitor monitoring need negative objectives offers offset offsets optic oxygen oxygenation paramagnetic parametric patients peaks phys pixel pixels pole positive potentially precession probe probes properties property protocol pulse quadrature quantitative quantitatively quenching recovery relation repeated respect respectively response segmented segments select sensitive sensitivity shortening simultaneous slice slope solubility spectrum spoiled steady therapy tissue tool tools treated treatment treatments tumor tumors type typical useful valuable variations vascular vessels volume water whereas