Meeting Banner
Abstract #1507

Combination of MR Spectroscopic and Diffusion Weighted Imaging of the Prostate for the Prediction of Tumor Aggressiveness

Gregor Thrmer1, Josephin Otto1, Christian Schrder1, Nikita Garnov1, Martin Reiss-Zimmermann1, Lars-Christian Horn2, Minh Do3, Jens-Uwe Stolzenburg3, Michael Moche1, Thomas Kahn1, Harald Busse1

1Dept. of Diagnostic and Interventional Radiology, Leipzig University Hospital, Leipzig, Saxony, Germany; 2Institute of Pathology, Division of Breast, Urogenital and Perinatal Pathology, University of Leipzig, Leipzig; 3Dept. of Urology, Leipzig University Hospital, Leipzig, Saxony, Germany

Active surveillance (AS) is currently discussed as an alternative to radical therapy for patients with low-risk prostate cancer. This option requires an accurate and reproducible technique to monitor the progress of the disease. Transrectal ultrasound-guided biopsy is only moderately suited because of its invasive nature and a substantial amount (40%) of undergrading. Multiparametric MRI, on the other hand, can provide quantitative parameters of tissue function that may help to assess cancer aggressiveness. This preliminary work evaluates the predictive value of combined DWI and MR spectroscopic parameters to discriminate indolent from aggressive carcinoma.

Abstract PDF Poster PDF

Keywords

absolute accuracies acknowledged acquisitions active aggressive aggressiveness alternative apparent appropriate assigned assuming better biopsies blinded breast calculating cancer cancers characteristic chemical choline chosen citrate classified coefficient combination combined component confirmed considered correctly correlation criteria curves dept derived determined diagnostic diagnostics differentiate differentiated differentiating diffusion discriminate discrimination distinguish division early error established evaluated example experienced finding findings function functional gold grade grades grant greatly guided healthy highlighted horn hospital identification identify included individual indolent institute intermediate invasive least lesions localization localized location martin matched materials measured mirror mount nearest normalized operating option pathology patient patients plots predicted prediction preliminary preoperative primary prior progress prospective prospectively prostate protocol qualitative radical radiologist radiology receiver refine relatively reproducible resolution respectively reviewed risk sampling scores secondary section sections slice slowly spectroscopic spectroscopy spectrum stages step substantial suggest suited support table thirteen threshold thresholds tissue transverse treatment trio tumor tumors ultrasound undergone urogenital urology versus volume whole