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Abstract #1503

Deformable Registration for Recovering Image Distortions in DWI MRI of the Prostate at 3T

Andriy Fedorov1, Luis Ibanez2, Kemal Tuncali1, Robert V. Mulkern1, 3, William M. Wells1, Clare Tempany, Fiona Fennessy1

1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Kitware Inc, Clifton Park, NY, United States; 3Department of Radiology, Children's Hospital, Boston, MA, United States

There is strong evidence of the value in using multiparametric MRI (mpMRI) to characterize prostate cancer. However, quantitative analysis of mpMRI is challenging due to the differences in resolution and acquisition-related distortions, which are particularly strong while imaging prostate using endorectal coil placed in air-filled balloon at 3T. Herein we propose a non-rigid registration approach fine-tuned to compensate for such artifacts by incorporating the prior knowledge about the nature of the distortion into the method. We evaluate the robustness and accuracy of the approach, and employ it to quantify distortions present in the DWI MRI of the prostate.

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Keywords

acceptable accuracy acknowledgments advances affected alignment analyzed apex appears applied approximate array artifacts aspects assessment axial balloon best biopsy calculating capable capsule cause challenging characterization children coil common complicated contour contoured control core correlation correspond covered currently deemed deformable deformation derived described diagnosis difficulty diffusion displacement displacements distance distortion distortions done dots error errors estimating evaluation exam examined example exists fact features fine gland grid herein hospital identify identifying improved included individual initialized insight invasive joint knowledge largest lead localization located magnitude marker markers maximize measured metric nature optimizer outer overlays park part particularly patient patients pelvic pixel portion posterior practical preliminary prepared propose prostate proven quantification quantified quantitative radiology recent recovered recovering reduce registered registration regular reliable represent residual resolution respectively response review rigid sample scales scanner series severe similarity since slice slicer spline stronger structural studies successful susceptibility tissue toolkit transformation treatment tumor tuned visually volume wall whole women