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Abstract #1484

Evaluation of Bilateral Breasts Response to the Hormonal Fluctuation of Menstrual Cycle Using 3D MRI

Jeon-Hor Chen1, 2, Siwa Chan3, Dah-Cherng Yeh4, Chih-Chen Kuo2, Jocelyn Lu1, Peter Fu1, MuQing Lin1, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Center for Functional Onco-Imaging, Department of Radiological Science, University of California , Irvine, CA, United States; 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 3Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; 4Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan

Functional breast symmetry is less known. In this study we used 3D MRI to investigate how the bilateral breast tissues of healthy women respond to the hormonal fluctuations during a menstrual cycle. Twenty-four healthy premenopausal Asian women were studied. The obtained CV and maximal percent difference of FV in the left and the right breast of all subjects were compared. The results demonstrate that during the MC, the CV of the fibroglandular tissue volume measured from the left and the right breasts shows a strong correlation (r > 0.7), so as the maximal changes of FV. The fluctuations of the morphological parameters between the left and the right breasts were not significantly different. Since most of breast cancers occur unilaterally, it would be interesting to investigate whether the functional response of tissues in bilateral breasts to hormonal stimulation is associated with different risks in developing cancer.

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Keywords

abnormality alterations among analyzed apparently assessed asymmetrical background bilateral bottom breast breasts cancer cancers channel china circularity coefficient coil completing computer concentric consecutive convexity correlated correlation cycle defined dense density detection developed developing deviation dimensional distribution dual endogenous enhanced evaluated evaluation examinations examples fluctuation fluctuations focused follicular functional general gradient graham healthy highly histological hormonal hormones hospital illustrate independent indicate indicating influence inst investigate investigated investigating irregularity known mainly mammography many materials maximal measure measured medical menstrual menstruation mode morphological morphologically morphology narrowly natl none occur operator operators optimal patients patterns percent peter physics potential preserved previous previously quantify radiological radiology received regarding respectively respond responds response risks scanner science seems segmentation separately significantly since slices slim smaller spatial static stimulation strong structural studied studies subject subjects summarized suppressed surgery symmetrical symmetry table thought timing tissue tissues twenty unilaterally variation veterans volume week weekly whether white woman women