Meeting Banner
Abstract #1433

Natural Progression of Fatty Infiltration and Beneficial Effects of Non-Pharmaceutical Intervention in FSHD Detected by Quantitative MRI

Barbara Janssen1, Nicoline Voet2, Rob Arts1, Christine Nabuurs1, George Padberg3, Alexander Geurts2, Baziel van Engelen3, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Rehabilitation, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

To assess natural progression towards a diseased state in FSHD-patients, and effects of Cognitive Behavioral Therapy and Aerobic Exercise Training (AET) we used muscle fraction measured by 1H-MRI of the thigh muscles as non-invasive biomarkers. A decrease in muscle fraction, corresponding to an increase in fatty infiltration, could be noticed in controls after a four month period of usual care. This increase was largest in intermediate affected muscles. Interventions appeared to beneficial to patient since no significant increase in fat infiltration could be noticed after four months after intervention, heavily affected muscles even showed an increase in muscle fraction.

Abstract PDF

Keywords

adductor affected appeared arise arts assess assessment asymmetric available behavioral beneficial biceps binary calculating care certain characterized chromosome clinical cohort coil common completing content contraction control controls correlation currently cycling decrease decreases derived detectable detected deterioration determined disease distance done either employ even event every exam exercise exponential extensive fatty financial fitting fixed force foundation fraction fractions genetically global grant hamstring head heavily included indicates infiltrated infiltrating infiltration initial intermediary intermediate intermediately intervention interventions invasive investigated involvement larger lead legs limb long made marker materials measures medical months muscle muscles muscular natural nearly needing neurology occurs outcome patient patients pelvic period pharmaceutical placed position positioned prevalence program progression protocol proven quadriceps quantitative randomly received recorded recruitment rehabilitation repeats sartorius scapular science score selected significantly since slice slices slow spin stabilized stage strength superior symptoms synthesis system therapies therapy toxic trained training treatment trigger trio underwent upper usual usually valuable weakness worth