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Abstract #1420

Monitoring the Delivery of Therapeutic Agents from Antibiotic-Loaded Bone Cement with Contrast-Enhanced MRI

Qingwei Liu1, Morgan B. Giers2, Alex McLaren3, Christopher S. Estes3, Michael R. Caplan4, Gregory H. Turner1, Ryan Y. McLemore3

1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Harrington Department of BioMedical Engineering, Arizona State University, Tempe, AZ, United States; 3Orthopaedic Residency, Banner Good Samaritan Medical Center, Phoenix, AZ, United States; 4School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States

Periprosthetic infection is a devastating complication of joint replacement. Traditional local delivery experiments have been explored In Vitro, but it is more important to study actual drug distribution in vivo. In this study, we used contrast enhanced MR imaging to track the delivery of small molecules through the complex delivery environment of bone, local tissues, and local blood flow. The elution of Gd marked drugs was observed after the surgery, which clearly showed continuous delivery of drugs in the tissue. The MRI T1 map technique was proved to be able to track the distribution of antibiotics in orthopaedic wounds.

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Keywords

accumulation actual agent agents anesthesia animals antibiotics antimicrobial away axial bacteria banner better biological biomedical blue body bone bridge canal cement clinical close closed complex complication concentration concentrations containing contrast correlated correlation decreases defect delivery depot designed determined devastating devices disconnect distribution drill dropping drug drugs elution engineering enhanced enter entry environment examined executed expanded expanding explored exponential fascia femoral femur fitting flow form future gadolinium gathered good groove health highly hours impregnated in vivo indicated induced ineffective infection infectious infinite institute joint known layers loaded local long longer longitudinally made maintained manage many maps marked mathematical matrix medical minutes model models molecules monitoring muscle neurological organisms patients periodically periods phoenix placed presence promising quadriceps quantification quarters rabbits rare related relationship release remains replacement residency school shortening skin slice slowly sought space spatial specified stab stable surface surgery systemic therapies therapy till tissue track tracking treating treatment vehicle vehicles whether wire wound wounds