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Abstract #1412

Longitudinal Characterization of Trabecular Bone Microstructure and Computational Biomechanics for Determining Treatment Effects in Postmenopausal Women

Yusuf A. Bhagat1, Maite Aznarez-Sanato1, Jeremy F. Magland1, Theresa M. Scattergood2, Peter J. Snyder2, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, University of Pennsylvania, Philadelphia, PA, United States; 2Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, Philadelphia, PA, United States

Recent advances in high-resolution structural imaging of trabecular and cortical bone and the use of these data as input into micro-finite-element (FE) models have shown potential for assessing the effect of treatment in patients with osteoporosis. Here, we report baseline and 1 year follow-up data in an ongoing investigation of women with low bone density (N=15) receiving either zoledronic acid or teriparatide, conducted at 3T and 7T. The baseline data show moderate associations with pQCT bone density while FE-derived axial stiffness is strongly correlated with bone volume fraction at the same site. Finally, repeat data in select subjects indicate large anabolic effects.

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Keywords

accelerated acceptable achievable acid acquisitions anabolic arms array arrest assessment associations axial biopsy blue body bone cancellation characterization coding coil computational computed cores course cross density derived designed despite detection diabetes digital diminishing displays distal distinguish division earlier edges either element ellipses elucidating enable endocrinology energy enhanced evident exceeds face fact fast features field finite formation fracture full green highlight identical identically identified improvement included insights intervention isolate laboratory linked longitudinal loss manually marker masked measures mechanics metabolism model modulus month months neck ongoing osteoporosis patient patients period peripheral permit plate poor post processing quality quantification quantifying quantitative randomized registered remodeling rendered repeat report representative resorption respectively reverse rigid risk scale scanned secondary section sensitivity serial significantly simulated skeletal slab spin stiffness strain strength stress strong stronger structural subjected subset suggesting surface system table take therapy tibia tibial tomography topology translational treatment twice underwent utilize virtual whole women year yielded young