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Abstract #1379

Monitoring of the Blood Supply to Artificial Cavity Used as a Site for Pancreatic Islet Transplantation

Daniel Jirak1, 2, Jan Kriz1, Eva Vodraskova1, Klara Zacharovova1, Frantisek Saudek1, Milan Hajek1

1Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 21st Medical Faculty, Institute of biophysics and informatics, Charles University, Prague, Czech Republic

To improve transplantation outcome, artificially created sites for cell transplantation have gained attention. The aim of our study was to evaluate the blood supply of the artificial cavities for islet transplantation in a preclinical rat model. Two biocompatible scaffolds were implanted subcutaneously and into greater omentum of the same animal. The blood supply of these devices was assessed by dynamic contrastenhanced magnetic resonance imaging within four weeks following implantation. Our results indicate that artificial device implanted into greater omentum possesses superior blood supply for the transplanted cells and optimal time for cell transplantation is one week after implantation.

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Keywords

accordance adequate agent anesthetized animals application artifacts artificial artificially attention basal biophysics blood brown carried caused cavities cavity cell cells clinical coil committee communities community confirmed connective considered contrast council covered created crucial cycle cycles days decreased delay destroyed detected detection determine device devices diabetes diameters dimensional directive drug enhanced equipped ethical every experimental exploited external female findings formation framework gained gallant gradient grant greater implantation implanted improve indicate influence informatics injected institute intensity islet kidney lateral layers located macroscopic manually matrix measured medical medicine meshes microscopic minimize model monitoring network normalized optimal outcomes pancreatic penetrated pixel plateau polymeric porous portal possesses pouch preferable project promptly protocols rats relatively repetitions republic resolution resonator reveal rich river rounded scaffold scaffolds scanner scientific seems selected seventh shaped site sites software space storm structure subcutaneous subcutaneously subjects superior supply supported surface tail target tissue transplantation transplanted treatment variability various vascular vein view week weeks