Observation of Gravitational Dependence of Regional Fractional Ventilation in Human Lungs with 2D and 3D Multi-Breath Washout Imaging of 3He and 129Xe

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accelerated according acquisition additional afterwards allowed animal anterior approximately around assessment assumed assuming axial breath breathing capable caused chosen circles coils concentration constant corrected curve curves dataset decay decayed density depend dependence dependent depolarization dictated disease divided dose doses duration early effort encouraged equal evaluate evaluated evolution exchanged exhale expected experiment exponential extended fact fast fitted five flex fractional free fully function funding future global gradients graham gravitational healthy held heterogeneity horizontal horn human humans inert inhale inhaled investigation irrespective kingdom likely linear location longer lowest lung lungs made manually maps martin materials matrix measured measuring mechanically might mixture monitoring mono mouth observation offset part period play plotted position posterior producing projection pulmonary quadrature reduced regional registration remained represent returns role scanner sections seems selected sensitive series slices slope south stages stripe stripes subsequent supine thorax tidal trend type upon ventilated ventilation volume volumes volunteer warrants washout whilst wild windowing