Meeting Banner
Abstract #1334

1H/19F MRI of Lung Angiogenesis with α vβ 3-Integrin Targeted Perfluorocarbon Nanoparticles

Anne Schmieder1, Shelton Caruthers1, John Stacy Allen1, Todd Williams1, Elizabeth Wagner2, Samuel Wickline1, Gregory Lanza1

1Washington University Medical School, St Louis, MO, United States; 2Johns Hopkins University, Baltimore, MD, United States

Asthma related proliferating bronchial neovasculature contributes to a sustained decrement in pulmonary function. In this study, a rat model of bronchial vascular proliferation was used to demonstrate noninvasive, high resolution molecular imaging of lung angiogenesis with dual 1H/19F MRI of αvβ3-targeted nanoparticles using a commercial 3T scanner. A novel steady state, ultrashort echo time technique was employed with a 3D radial readout scheme. The successful imaging of lung angiogenesis with this technique demonstrates a clinically translatable approach to monitor temporal-spatial changes in airway vascularity and potentially to deliver and monitor antiangiogenic therapy in order to ameliorate the progression of moderate to severe asthma.

Abstract PDF

Keywords

acute adjusted affects airway animals appreciated artery assess asthma balanced birdcage blood briefly bronchial buffer cancer carbonate care cell cells characterization children chronic circulation clearance closely coil combined components conjunction consisted coronal corp coupled days decreased density described dramatic dual dynamic economic employed employing employs emulsified endothelial excretion expansion expressed facto fluorescent fluorine glycerin green health highly home human impact inflammation inflammatory instrument intestine invest john johns labeled lecithin ligated ligation light liver lives located long lung macrophages marked maximize microscopic million minimal mixtures model models mole molecular near nominal noninvasive novel nuclei obstruction occluded offer open opposed optimize oversampled post potential prepared previously progression proliferating proliferation pulmonary quality rats readout receive recognized reconstructed reduce resembles resolution resolutions ribs sacrificed scanner scattering school sensitivity separated severe significantly site sites skin slice space spatial spectrum spleen surfactant sutured symptoms targeted targeting temporal tuned typical ultimately ultrashort uninjured unique ventilated wall winter wound