Meeting Banner
Abstract #1331

Tracer Kinetic Parameters Estimated with Rapid DCE-MRI in Patients with Muscle-Invasive Cancer of the Bladder Are Able to Distinguish Between the Effects of Neo-Adjuvant Chemotherapy and Residual Tumour

Stephanie Donaldson1, Bernadette Carrington2, Suzanne Bonington2, Richard Cowan3, Jeanette Lyons3, David Buckley4

1Christie Medical Physics and Engineering, The Christie, Manchester, Greater Manchester, United Kingdom; 2Department of Radiology, The Christie, Manchester, United Kingdom; 3Department of Clinical Oncology, The Christie, Manchester, United Kingdom; 4Division of Medical Physics, University of Leeds, Leeds, United Kingdom

Treatment of bladder cancer with chemotherapy and radiotherapy results in inflammation which mimics residual tumour on conventional MR images. Dynamic contrast-enhanced (DCE-) MRI was performed in eighteen patients following neo-adjuvant chemotherapy. Data obtained from abnormal areas observed on conventional MR images were analysed with a two-compartment exchange model to obtain estimates of perfusion and permeability. The descriptive parameter, relative signal intensity at 80 s (rSI80s) was calculated. The bladder was examined for evidence of residual tumour and/or post-chemotherapy effect. DCE-MRI parameters obtained in areas of residual tumour were significantly higher than those obtained in areas of post-chemotherapy effect.

Abstract PDF

Keywords

able abnormal acquisition agrees array arterial arteries axial bladder breath cancer capable capillary carcinoma cell chemotherapy classified clinical coil compartment contrast covering curves defined descriptive determine differ differed differentiating difficult discriminating distinguish distinguishing division dynamic eighteen engineering enhancement evidence examination examined example exchange existing external extracellular functions greater hold identified iliac individual inflammation input intensity inter interpolated interpretation invasive investigate kinetic kingdom making materials matrix measured median medical mimicking mode muscle oncology pathology patients pelvic perfusion physics plasma post product quartile radiology radiotherapy rapid residual resolution respectively secs sensitivity separated significantly sites space specificity structures student studies subsequently surrounding suspicious table temporal tracer transferred transitional treated treatment underwent vibe volumes volumetric whether whole