Meeting Banner
Abstract #1301

Pancreatic and Hepatic Fat Measurements Using 1H MRS and MDIXON with Flexible Echo Times.

Roshan Livingstone1, Paul Begovatz1, Sabine Link1, Bettina Nowotny1, Birgit Klueppelholz2, Guido Giani2, Juergen Bunke3, Michael Roden1, 4, Jong-Hee Hwang1

1Institute of Clinical Diabetology, German Diabetes Center, Dsseldorf, Germany; 2Institute for Biometry and Epidemiology, German Diabetes Center, Dsseldorf, Germany; 3Philips Healthcare, Hamburg, Germany; 4Department of Metabolic Diseases, University Clinics, Heinrich Heine University, Dsseldorf, Germany

1H-MRS is considered the gold standard for liver fat measurements, however, it is unclear whether H-1 MRS is more accurate for the pancreas than DIXON methods. A flexible 2-point mDIXON method (TE1/TE2 = 1.12/2.0 ms) was compared to 1H-MRS for fat fraction of the liver and pancreas in 19 volunteers. Values of hepatic fat fraction by mDIXON and 1H-MRS correlated well with each other (r = 0.96, p<0.00001), however, in the pancreas a correlation of (r=0.66, p<0.001) was found, which was probably attributed to differences in the amount and distribution of fat between the two organs.

Abstract PDF Poster PDF

Keywords

abdominal ability accurate acorn additionally advantage alcoholic allows amount analyses analyze analyzed anatomy applied approved array assessment attributed avoiding best biometry board cell channel chosen clinical clinics coil comparatively compound conducted consented considered consistently content contributions correlated correlation date diabetes diseases distribution dots employing ensure epidemiology evaluate even except expressed false fast fatty flexible fluctuated fraction gland goals gold gradient hamburg healthy hepatic homogeneous human identical in vivo infiltration institute introduced islets iterative lead limit link lipid liver local locally loosely materials matrix measure medicine metabolic microscopic noise nuts obesity often ones organ organs package packed pancreas pancreatic peak pixel placed positioning potentially pride processing protocol pulse quantification radiology receive recently recruited regarding review sensitivity shim short silver since slices software spring steam studies subjects take though tissue torso type typical unclear understood utilized visceral volume volunteers water whether white widely