Meeting Banner
Abstract #1279

Towards Clinical MRI Measurements of Gastric Function and Emptying for a Standardised Liquid Nutrient Meal: Validation of Data Acquisition and Analysis.

Caroline L. Hoad1, Helen Parker2, Nicola Hudders2, Carolyn Costigan1, Eleanor F. Cox1, Luca Marciani2, Mark R. Fox2, Penelope A. Gowland1

1Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

This study develops a clinically applicable protocol to assess gastric function using MRI. A 400ml doped nutrient meal was ingested by ten healthy volunteers and their stomachs imaged using an optimised TrueFISP sequence. Total gastric (TGV) and liquid only volumes (LGV) were measured by 3 observers using an intensity based image segmentation algorithm. These volume data were then fitted to a complex model of gastric emptying to parameterize the secretion, relaxation and emptying of the stomach. Coefficients of variance (CV) were determined for the volumes and found to below 5% for all volumes greater than 100 ml.

Abstract PDF Poster PDF

Keywords

abnormal accurate acquisition allow allowed applicable appropriate aspects assessment astronomy biomedical bowel breath chose clicks clinical closing coefficient coil column committee complete completely complex comprehensive connected consent considerably consumed content contents contrast control customized define defined delineated detect determine differentiate digestive dilution diseases doped dynamic dyspepsia element emptying enough ethics excellent excluded extent faster feedback field fits fitted fitting forty fully function functional funding gaps gastric graph growing healthy hospitals identified included initial intensity inter invasive investigation kingdom larger late linear liquid local long manual meal measured measuring minutes model models needed nutrient observer observers optimized organs parameterized paresis parker particular percentage physics placed practice probably protocol pump reduce reduced related remained remaining routine scanned scanner secretions seed segmentation sense shaded simplified slice slices slow software stomach studies subject subjects summary symptoms table term thin took torso towards turbo unit user validated variance variation version volume volumes volunteer walls whilst written