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Abstract #1275

Measuring T1 of Chyme in the Ascending Colon in Health and Diarrhoea Predominant Irritable Bowel Syndrome

Caroline L. Hoad1, Klara Garsed2, Luca Marciani2, Eleanor F. Cox1, Carolyn Costigan1, Robin C. Spiller2, Penelope A. Gowland1

1Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

T1 of the chyme in the ascending colon (AC) was measured using an inversion recovery TrueFISP sequence in healthy volunteers and patients with diarrhoea predominant irritable bowel syndrome (IBS-D). Data was fitted to both 1-compartment and 2-compartment T1 models. IBS-D patients showed a higher mean T1 in the chyme of their AC than the healthy volunteers for both the 1-compartment and short component of the 2-compartment model. This difference may have been due to faster small bowel transit or a reduced rate of fluid absorption in the AC.

Keywords

abdominal absorption acids adjusted aliment allow allows always amount applied approved approximated arbitrary ascending assuming astronomy attributed bacteria better body bottom bowel breath carried chyme clinical coil colon committee compartment compartments complex component components condition consistent controls currently curves defined delivered described describing determine differing difficult disease diseases dissatisfied effective either erratic ethics extremely fast faster fasting fatty find fitted fraction fractions free full function funded gain good graph habits health healthy heterogeneity highlighted horizontal hospitals illustrating in vivo intensity inter intra inversion irritable keeping kingdom likely local long longer made male matched matrix measured measuring mechanisms middle mixture model moved multiplied needed numerical occurred overlap pain partly patients physics physiology poor position predominant press progress properties pulses rather recent recipes recovery reduce related remaining sample scanning sense short simple slice spiller statistical student studies subject subjects suggested symptoms syndrome transit treatment trust typical underestimated underlying understanding unit units useful volunteers whether written