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Abstract #1265

Myocardial T1 Mapping in Swine with Non-Ischemic Heart Failure with Comparison to Changes in Specific Collagen Types

Maureen N. Hood1, 2, Ting Song1, 3, Peter Bedocs4, John F. Capacchione4, Christine E. Kasper2, 5, Mark C. Haigney6, Vincent B. Ho1

1Radiology & Radiological Sciences, Uniformed Services University, Bethesda, MD, United States; 2Graduate School of Nursing, Uniformed Services University, Bethesda, MD, United States; 3Global Applied Science Laboratory, GE Healthcare, Bethesda, MD, United States; 4Anesthesiology, Uniformed Services University, Bethesda, MD, United States; 5Nursing, department of Veteran Affairs, Washington, DC, United States; 6Cardiology, Uniformed Services University, Bethesda, MD, United States

T1 mapping may be a promising technique to quantify myocardial changes in heart failure even when the subject cannot hold their breath. T1 mapping using modified look-locker with saturation recovery in this small swine study shows a quantitative difference in T1 value between healthy baseline and heart failure hearts. The immunochemistry suggests a change in amounts of Type I, III and VI collagen in the myocardium between the control and heart failure swine, but more research needs to be done.

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