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Abstract #1229

Monitoring Amyloid Deposition and Therapeutic Clearance Using Equilibrium Contrast MRI

Adrienne E. Campbell1, 2, Anthony N. Price3, Stephan Ellmerich4, Paul Simons4, Raya Al-Shawi4, Rupinder Ghatrora1, Tammy L. Kalber1, Philip N. Hawkins4, Roger J. Ordidge5, James C. Moon6, Mark B. Pepys4, Mark F. Lythgoe1

1Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, United Kingdom; 2Department of Medical Physics and Bioengineering, University College London, London, United Kingdom; 3Robert Steiner MRI Unit, Imaging Sciences Department, Hammersmith Hospital, Imperial College London, London, United Kingdom; 4Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London, United Kingdom; 5Centre for Neuroscience, University of Melbourne, Melbourne, Australia; 6Heart Hospital and Division of Medicine, University College London, London, United Kingdom

Equilibrium contrast MRI (EQ-MRI) was applied for the detection and monitoring of systemic amyloidosis in mice. Modest amyloid deposits in the heart were clearly detected by EQ-MRI even when cardiac function was not measureably impaired. An excellent discrimination between amyloidotic and control mice was observed in the liver where amyloid load is substantial. In addition, EQ-MRI was able to monitor the induction of amyloidosis and regression of amyloid deposits following the administration of a novel therapy, indicating the potential of this technique to monitor therapeutically induced amyloid regression.

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Keywords

acute addition advanced animals anti antibody applicable assess assessed assessment available bioengineering biomedical blood bolus cardiac child cine circulation clearance clearly coil college concentration connective contrast control correlation cross deposition deposits detecting detection direct directly distribution division doses dotted double equilibrium excellent expansion experienced expression extensive extracellular extracellularly fibrils frames function furthermore gadolinium gated global health heart histological hospital human impaired imperial in vivo index individual induced inducible induction infusion initial initially institute interpretation invasive involved involvement kingdom linear liver load local locker mark marker markers medicine mice model modest monitored monitoring morbidity mouse myocardium nature need normalized novel observer often oral organs physics pixel plotted positive post price promote protein proteins quantifying rank regression removal report resolution returned roger samples scanner scanning sciences score segment serially serum slice slices software solid sought space spleen steiner straightforward suggesting support systemic tail therapeutic therapeutically therapies therapy tissue tissues treatment trend trends unit vein volume