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Abstract #1203

Probabilistic MRA Template of the Macaque Putamen for Guiding Convection Enhanced Delivery

Zhan Xu1, Marina Emborg2, 3, Do Tromp1, Nagesh Adluru1, Martin Brady4, Raghu Raghavan4, Ken Kubota5, Andrew L. Alexander1, 6

1Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, Madison, WI, United States; 2Department of Medical Physics, University of Wisconsin Madison, Madison, WI, United States; 3Wisconsin National Primate Research Center; 4Therataxis,LLC, Baltimore, MD; 5Kinetics Foundation, Los Altos, CA, United States; 6Department of Medical Physics and Psychiatry, University of Wisconsin Madison, Madison, WI, United States

In our CED research on rhesus macaque monkeys for treatment of Parkinson's disease, the location of infusion spot within brain highly determines the effect of the delivered drug. We generate a probabilistic MRA template of putamen on both hemispheres. By overlaying the template with T1W template, which is generated by another member of our group with identical subjects, we find out blood vessels mainly locate in lateral surface of putamen, there is barely any vessel within. Also a high probability region is found in this MRA template, where we should avoid during infusion in any future subject

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Keywords

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