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Abstract #1191

Feasibility of Mitral Valve Blood Flow Quantification by 7D PC-SSFP

Marijn P. Rolf1, Mark BM Hofman1, Joost PA Kuijer1, Rob J. van der Geest2, Aernout M. Beek3, Albert C. van Rossum3, Rudolf M. Verdaasdonk1

1Physics and Medical Technology, ICaR-VU, VU University Medical Center, Amsterdam, Netherlands; 2Radiology, Leiden University Medical Center, Leiden, Netherlands; 3Cardiology, ICaR-VU, VU University Medical Center, Amsterdam, Netherlands

The feasibility of a new 7D PC-SSFP sequence for mitral regurgitation volume quantification is assessed. The 7D PC-SSFP sequence implementation is based on a balanced SSFP gradient scheme with velocity encoding. Mitral volume flow was determined in ten healthy subjects and in two patients with mitral insufficiency. It was measured directly at the mitral valve using 7D PC-GE and 7D PC-SSFP, and indirectly using aorta flow and left ventricular volumes. Images showed reasonable quality, although occasional respiratory motion artifacts were noted. Regurgitation volumes in healthy subjects were not significantly different from zero and a clear regurgitation was observed in both patients.

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Keywords

accurate acquisition adjusted amongst aorta aortic assess assessed assessment balanced beneficial benefit blood breathing cardiac cardiology causing challenges chamber chest clear clinical comparable continuous contours contrast curves cycle decision determined deviation direct directly displacement drawn duration ejection encoding every excitation extensive feasibility feasible flow flows gating geest gradient healthy heart herein implemented important improved indirect indirectly insufficiency integration introduced investigated jets locally magnitude making management mark mass matrix measure measured medical minutes morphological motion movement multiplied optimized orthogonal others outcome output overall paired parallel patient patients physics planned previously pronounced quality quantification quantify radiology reasonable regular regurgitation resolution respiratory scanned scheme segmented segments shim significantly slice spatial still stroke student subject subjects suffered support systole technology temporal topic treatment validated valve valvular velocity ventricular view visualize voids volume volumes volunteers whole zero