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Abstract #1103

Cerebral Autoregulation Is Associated with Skeletal Muscle PH in Patients Suffering from Chronic Fatigue Syndrome Both at Rest and During Dynamic Stimulation

Jiabao He1, Kieren G. Hollingsworth1, Julia L. Newton2, Andrew M. Blamire1

1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom

Chronic Fatigue Syndrome (CFS) is related to a compromised skeletal muscle response to exercise and autonomic dysfunction. We hypothesised that if CFS has a central mediating factor then there would be a correlation between the pH handling in skeletal muscle and cerebral vascular regulation. We performed ASL MRI to measure CBF and 31P MRS to probe skeletal muscle pH at rest. We conducted fMRI concurrently with the Valsalva manoeuvre, as well as 31P MRS to measure recovered pH after plantar flexion exercise. We found there is a close relationship between skeletal muscle pH and cerebral vascular regulation in CFS.

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Keywords

abnormality acidity acquisition adaptation almost anatomical anterior autonomic avoid blood body brain cardiac central cerebral challenge characteristic chronic circulation clear clinical closely coil conditions constriction contraction controls corpus corrected correlated correlation course covered criteria cycle duration dynamic dysfunction ethics exercise exhaled exhales explored fatigue feedback fixed flow forcefully frequent function functional funding global graphical handling health healthy hence impaired impairment indicates individual inflow instructed interference intolerance investigate investigation kingdom local magnitude maintain management manner marked matrix measure measured mediating module morris muscle muscular nervous newton north paradigm parallel part particular patient patients period physiological plantar positioned posterior press pressure previous processed projection protocol quantification radiographer readout real recovered recruited reduced reflect regulation related resolution response rest resting scanner schematic selected sensitive service seventeen short significantly skeletal slices smith spectra spin spiral static stimulated stimulation stimulus subject subjects suffering support symptoms syndrome system thank transient transmission underwent upon vascular volume wear whole