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Abstract #1100

Optimization of T1 Measurement Using Mixed Flip Angle and TR

Yu Sub Sung1, Seonjoo Kwon1, Woo Hyun Shim1, Gyunggoo Cho2, Hyungjoon Cho3, Jeong Kon Kim, 14, Bruce Rosen1, Young Ro Kim1

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States; 2Korea Basic Science Institute; 3Ulsan National Institute of Science and Technology; 4Asan Medical Center, University of Ulsan

Accurate determination of T1 values in the brain is clinically important for assessing various neurological diseases and also for the successful execution of perfusion and dynamic contrast agent studies. In this work, we propose a clinically practical T1measurement method using the widely available 3D gradient echo sequence and the optimized acquisition strategy with mixed FA and TR for efficiently and accurately calculating T1 maps in the brain. This new combination method is an attractive alternative to other conventional methods, providing accurate T1 measurements in a reasonable scan time.

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Keywords

accuracy accurate accurately acquisition acquisitions agent alone alternative although appeal applied assess attractive available axial basic biomedical brain calculating calculation cerebral chosen clinically closer combination combinations combining compensates computed concentrations containing contrast coverage currently dependence dependent despite determination determined developed diagnosis dimension disease distilled dynamic efficiently either epilepsy errors evaluated execution experimentally fact fast finally fitting frequently general gold gradient hospital hypothesized important improved improves inaccurately inclusion influence institute inversion investigated involved limited long maps materials measured medical minutes mixed national negative newer noise nominal optimal optimization optimized optimizing otherwise performance perfusion phantom plastic poor practical practice produces proper propose pulse quantification random rapid reasons recalled recovery reduce related relatively repetition representative respectively sampled samples sampling scanner science sets shim significantly simulation specified spin spoiling strategies studies successful suffers suggested sung target technology tubes underestimated underestimation unless variable various water white widely young