Meeting Banner
Abstract #1084

Mapping Human Subcortical Areas in vivo Based on T2*-Weighted, R2* and Phase Images at 7 T

Bing Yao1, Zhongming Liu1, Peter van Gelderen1, Jeff H. Duyn1

1Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

Subcortical brain regions such as the basal ganglia and thalamus have important roles in brain function that may be compromised by many diseases. Their accurate localization is often challenging with clinical MRI contrast such as T1 and T2 that are optimized to distinguish the main tissue compartments of CSF, grey and white matter. Previous work has shown that magnetic susceptibility contrast (T2* weighted magnitude, R2*, and phase images) may provide additional contrast in subcortical regions. Here, we set out to generate a brain atlas aiming to distinguish the sub-regions in the subcortical areas that are not clearly visible in a conventional T1-based atlas.

Abstract PDF

Keywords

abundant acceleration accentuating accurate acquisition additional advanced align although anatomic anatomical anterior appear atlas atlases attributed axial background bandwidth basal bing boundary brain capsule challenging clear clearly clinical close combination compartments compromised containing content continuous contrast contrasts convolving cortical decrease decreased derived diamagnetic diseases distinct distinguish distinguishable especially exponential facilitate field finally fitting flat function ganglia generate generated gradient guidelines health healthy human identifiable important in vivo indicating individual induced institutes intensity interestingly internal investigating iron kernel lateral linear little localization location magnitude mapping maps marked materials mono much national nearby neighboring nonlinear normalized nuclei nucleus often operations optical optimized overall paramagnetic part participated particular pathways peter poorly previous profiles quantitative radiation radiology rage reaching registered registration registrations relatively relay resolution rich roles section sense sensory similarly since slice slightly stain staining strong stronger strongest structures studies subjects subtracting surrounding susceptibility thalamus tissue transformation unwrapped various ventral visible volunteer volunteers white