Meeting Banner
Abstract #1054

Imaging Vitreous Oxygen Tension with Rapid Look-Locker T1 Measurement and Calibration with ex vivo Eyes

Eric R. Muir1, Yi Zhang1, Oscar San Emeterio Nateras1, Timothy Q. Duong1, 2

1Research Imaging Institute, UT Health Science Center, San Antonio, TX, United States; 2Ophthalmology, UT Health Science Center

Abnormal vitreal oxygen tension (pO2) has been implicated in a number of ocular and retinal diseases. MRI could be used to non-invasively map pO2 of the human vitreous since T1 is affected by pO2. In this study MRI methods were developed to measure pO2 in the human vitreous using the Look-Locker sequence to rapidly measure T1 to minimize eye motion. Calibration of T1 to pO2 was made using ex vivo vitreous in addition to water phantoms to provide more accurate pO2 calculation from T1. Human vitreous pO2 was found to be 26.87.5mmHg with MRI, comparable to reports of invasive measurement.

Abstract PDF

Keywords

abnormal accurate addition additional anatomy animals anterior around asked baboon blink bubbled calculation calibrate calibration chamber channel circulating close coil concentration correction custom dependent desired determine develop deviation diabetic diameter diseases distilled electrodes equation euthanasia eyes fast female fiber find fitted five fixate function future glass gradient head health heated hours human humans important impossible improve in vivo inserted inserting institute intercept invasive inversely inversion invest kept larger least lens linear linearly locker long look made male maps matrix measure measured movement much nelson nitrogen nuclear ocular open ophthalmology optic otherwise oxford oxygen partial periods phantom phantoms physiology placed potentially pressure previous probe prone providing pulse rabbit rapid rapidly readout readouts receive regression repetitions reports require resolution retinal saline scaled science sealed shots slice slightly slope solid spatial spoiled squares structure studies subject subjects surface surgery surrounding target temperature tension timothy together train tung undergoing unique various vials vitreous volunteers warmed water whole