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Abstract #1039

Assessing Demyelination & Remyelination Using MRI Texture Analysis

Yunyan Zhang1, Axinia Doering2, V Wee Yong3

1Depts of Radiology and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; 2Dept of Paediatrics, University of Calgary, Calgary, AB, Canada; 3Dept of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Twelve mice with induced demyelination and spontaneous remyelinaiton in dorsal spinal cord were imaged at day 0 (intact myelin), and at 7 (demyelination), 28 and 35 (remyelination) days post injury. MRI texture was assessed in lesions and control white matter of the spinal cord over time. We found that the change in MRI texture parallels that of demyelination and remyelination. While lesion area demonstrates similar evolving pattern texture analysis further suggests the presence of residual injury at day 35 despite significant remyelination. MRI texture analysis may be a promising measure of myelin pathology, which warrants further verification.

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