Meeting Banner
Abstract #1022

Restoring Cerebro-Vascular Reserve in Carotid Artery Disease

Kay Jann1, Manuela Wapp2, Patrik Michel3, Marwan El-Koussy2, Frauke Kellner-Weldon2, Martinus Hauf2, Gerhard Schroth2, Andrea Federspiel1

1Dept. of Psychiatric Neurophysiology, University Hospital of Psychiatry / University of Bern, Bern, Switzerland; 2Institute for Diagnostic and Interventional Neuroradiology, Inselspital / Bern University Hospital, Bern, Switzerland; 3Dept. of Neurology, University Hospital Lausanne, Lausanne, Switzerland

In carotid artery disease (CAD) information about cerebral blood flow assessed by pCASL identified brain areas with reduced cerebro-vascular reserve capacity (CVR) due to the occlusion of a feeding vessel. A reduction of CVR was associated to cognitive deficits in CAD. In this study we investigated whether revascularization therapy restores CVR in the affected vascular flow territories in a 12 month follow up. Our results indicate the ability of revascularisation therapy to restore CVR in patients with CAD. Specifically, the CVR of the anterior watershed area was markedly increased after intervention

Abstract PDF Poster PDF

Keywords

ability able accompanying acquisitions administration advantage affected afore agent allows altered anterior arterial artery assessment basis block blood brain calculation capacity carotid cerebral cognitive conditions control deficits delay dept diagnostic disease duration eight enriched especially feeding flow fourteen function functioning furthermore grade gradient healthy hemisphere hospital identified improves indicate indicates institute intervention investigate investigated labeling like markedly marker middle might necessity neurology neurophysiology next occlusion often ongoing outcome parallel particularly patient patients perfusion physiological placed positive posterior project proper proven psychiatric psychiatry pulse pulses quantified readout reduced repeated reserve respectively restoration restore restoring selective shaped shed slice slices space specifically spin step subtraction suggested tagging territories therapy vascular vessel volumes water watershed whether window year