Meeting Banner
Abstract #0998

Amyloid Plaque Detection in a Mouse Model at 17.2 Tesla

Alexandra Petiet1, 2, Luisa Ciobanu2, Marc Dhenain3

1Brain and Spine Institute, Paris, Ile-de-France, France; 2CEA NeuroSpin, Gif-sur-Yvette, Ile-de-France, France; 3CEA MIRCen, Fontenay-aux-Roses, Ile-de-France, France

Amyloid plaques, extracellular deposits of b-amyloid peptides, are early markers of Alzheimers disease. The majority of them in the cortex and hippocampus are poorly loaded with iron, which requires high sensitivity to detect their presence. We used a 17.2-Tesla magnet to achieve an isotropic resolution of 30 um in 7 hours in a mouse model. The image quality achieved revealed many amyloid plaques throughout the brain. Using very high field magnets allows very high resolution imaging in short times and the increased magnetic susceptibility required for amyloid plaque imaging will benefit their detection in live mouse models.

Abstract PDF Poster PDF

Keywords

able achieve achieved additional aging animals appear arrow arrows association available avoid background become becomes benefit brain brains built challenges characterized chelate clearly closeup coil common comparable constitute contrast cortex course density deposits described detect detected detection diagnostics disease diseases early enough extracellular field flash form gadolinium gradient gradients green highly holder home hypothesis hypothesized identified improve improvement in vivo indicated institute iron isotropic larger lesions live load loaded longitudinal magnet magnets mainly matrix mice microscopic microscopy model models months mouse noise ones passively placed plaque plaques poorly positioned previous previously prior protocol protocols quality registered resolution rich roses running sensitivity slew spine spots stained strength studies supported surface susceptibility table target therapeutics together translate type typically view visible whole yielded