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Abstract #0991

Early Alzheimers Disease: Does Gray Matter Loss Pattern Correlate with Naming Impairment?

M. Vittoria Spampinato1, Ryan Parker, Karen Elizabeth Patrick, Zoran Rumboldt1, Jacobo Mintzer2, Hrvoje Vavro3

1Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States; 2Neurosciences, Medical University of South Carolina, Charleston, SC, United States; 3Diagnostic and Interventional Radiology, University Hospital Dubrava, Zagreb, Croatia

We used voxel-based morphometry to assess patterns of gray matter (GM) volume loss in subjects with early Alzheimers disease with and without naming impairment.

Keywords

analyses assessed available bilateral blue boxes brain characteristics clinical cognitive cohort correction correlate dementia demographic demographics diagnosed diagnosis diagnostic differ disease distribution done early equal error evaluated extent family findings five forty frontal general gray greater hemisphere hospital impairment implications included initiative involved involvement item linear lobe lobes longitudinal loss materials measures median medical mild model months naming newly nucleus objective overall paired parametric parietal parker participation patient patients pattern patterns performance potential processed prognosis progression radiological radiology rating repeated retrieval revealed scale science score seventy severity significantly smaller south specifically stage statistical subjects temporal therapy thirty volume whereas wise women word