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Abstract #0981

Anterior & Posterior Hippocampal Memory Networks in Aging as Revealed by Resting State fMRI

Y.C. Shih1, 2, Kayako Matsuo2, S.H. A. Chen3, Toshiharu Nakai4, Y.C. Hsu5, F.H. Lin1, W.Y. I. Tseng2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Center for Optoelectronic Biomedicine, National Taiwan Univerity College of Medicine, Taipei, Taiwan, Taiwan; 3Division of Psychology, Nanyang Technological University, Singapore , Singapore; 4National Center for Geriatrics and Gerontology, Aichi, Japan; 5Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University

We performed resting state fMRI to investigate the functional connectivity of elderly people placing seed regions in the anterior and the posterior hippocampus using a . A regression model. The anterior hippocampus seed revealed a memory network including an anterior part of the temporal lobe and the insula. In contrast, the posterior seed revealed a network including the posterior cingulate cortex (PCC). The was used to efficiently detect the functionally coherent cerebral regions with these hippocampus seeds. We hypothesized that elderly people show the different signal coherence pattern in the hippocampal memory network. Eelderly group demonstrated higher signal coherence in the left right PCC, right insula and superior right anterior temporal lobe with the posterior hippocampus and anterior hippocampus than the young group. It would be explained eElderly people may have a compensatory mechanism to ensure higher cognitive memory functions caused byaffected by aging and experiences.

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Keywords

activation aging amplitude analyses anatomy anterior applied aversion bilateral biomedical biomedicine brain cerebral codes cognitive coherence coherency coherent coil college color compensating compensatory computed connectivity contrast contrasts cortex courses defined derivatives detect discrimination divided division elderly emotional employed engineering episodic examination experienced extract extracted fifteen filtered findings functionally functions general generated geriatrics gerontology handed head healthy house hypothesized included index indicated indicates individual individuals inferior institute intensity interleaved investigate involved japan kinds laboratory lathe linear lobe maintenance maps masks matrix mechanism medial memory mental might mini model national navigation network networks neural node normalization optoelectronic part participants pattern people perceptual placing posterior preprocessed previous psychology random realign realignment reflect regressors relationship represent representations respectively resting resultant revealed sample scanner seed seeds semantic several significantly slice smoothened software space spatial spatially speed spurious statistic statistics studies subject suggested superior systems technological templates temporal trio uncorrected verify volumes white written years young younger