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Abstract #0973

Abnromal Changes in Default Mode Network in Alzheimers Disease & Mild Cognitive Impairment Subjects Investigated by DTI & Resting-State FMRI

Xiaozhen Li1, Tie-Qiang Li2, Raffaella Crinelli1, Hakan Fisher3, Anna Rieckmann4, Lars-Olof Wahlund1

1Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; 2Department of Medical Physics, Karolinska Institutet, Stockholm, Sweden; 3Department of Psychology, Stockholm University, Stockholm, Sweden; 4Aging Research Center, Karolinska Institutet, Stockholm, Sweden

In this study, we evaluated the abnormal changes of both microstructure and functional connectivity in Default Mode Network (DMN) in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) subjects using Diffusion Tensor Imaging (DTI) and resting-state function MRI (rs-fMRI).We found MCI shares features with AD. The structural and functional connectivity of DMN in both AD and MCI patients are abnormal.Our investigation is beneficial to further understanding of the structural and functional changes of AD in different stages.Moreover, it may contribute to an improved differential diagnosis in AD and MCI which are often clinically difficult to distinguish.

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Keywords

abnormal acquisition addition aging among anisotropy anterior atlas atrophy axial band bilateral body calculation calling care cause channel clinical clinically close cluster coefficient cognitive coil connectivity consistent contribute controls correction correlation cortices covariates cubic datasets decreased decreasing default degeneration dementia dependent deposition diagnosis diffusion diffusivity disease distinguish duration eddy elder elevated equipped evaluated evolving eyes features filter fisher fitting fractional frames frequency frontal functional gender global gradient gradients head healthy impairment included increasing instructed investigated long maps mechanisms medical metabolism middle might mild mode motion network neurobiology neuronal orientations package parietal particularly pathological patients physics post posterior process processed processing program protein protocol psychology recalled reduced removed resolution respectively resting sample sampling scanner sciences score selecting separately series sets shares significantly since slice slices spin squares stages starts statistical structural structures subjects superior support table template temporal tensor thick tool transformation transformed transitional trend types understanding view volumetric vulnerable years yield