Meeting Banner
Abstract #0970

Probing Age-Dependent Cerebrovascular Alterations in the Tg2576 Mouse Model of Alzheimer's Disease by Magnetic Resonance Angiography at 17.6 T

F Kara1, E S. van Dongen1, R Schliebs2, M A. van Buchem3, H J.M. de Groot1, A Alia1, 3

1Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands; 2Department of Neurochemistry, University of Leipzig, Leipzig, Germany; 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

In this work we present the first ultra-high field (17.6 T) MR Angiography study to monitor age-dependent cerebrovascular alterations in the Tg2576 mouse model of AD. The blood flow alterations observed in middle cerebral artery and anterior communicating artery increased in transgenic mice compared to wild-type mice over time. Histological data revealed that these alterations such as signal voids might be correlated with severity of A type of cerebral amyloid angiopathy. Our results show that ultra-high field MRA is a powerful tool to monitor blood flow alterations longitudinally in living mice.

Abstract PDF Poster PDF

Keywords

abnormalities achieved addition alterations altered analyses anesthetized angiography anterior applied appointed artery assessment attached bars basis birdcage blood brain brains breeders calculation causal caused cerebral chemistry coil collected confirmed constantly control controls coronal cortex decrease dependent deposition described detected developed diameter dimensional disease diseases elevation error evaluation extents field flight flow frequency frequently genders generating gradient help histological in vivo individual inflow inner insert institute intensity intervention kindly known leading linked load local magma magnet many marked matched medical mice middle might model models monitor monitoring month months mouse noise oxygen part partial partly pathological peptide plaque plaques previously probe probing procedure projections providing quantitative radio radiology recent reduction related require resolution revealed score sections semi served severities severity shear shielded slice slices software stained staining statistical stress student studies system systems tail thank therapeutic tool type ultra useful validate various vascular vertical vessel vessels view viscosity visual voids wall walls wide wild