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Abstract #0944

Detection of Spontaneous Pain Due to Chronic Pain in the Rat

Yuko Kawai1, Masahiro Umeda1, Yasuharu Watanabe1, Toshihiro Higuchi2, Chuzo Tanaka2

1Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan; 2Neurosurgery, Meiji University of Integrative Medicine, Kyoto, Japan

Introduction: Spontaneous pain and allodynia are the common complaint in chronic pain conditions. The purpose of this study is to detect brain activation spontaneous pain using AIM MRI in a segmental spinal nerve ligation (SNL) model.Methods: The right L5 spinal nerves were ligated with silk sutures. The AIM MRI were acquired using a 4.7-T MRI system.Results: Spontaneous pain induced brain activation was successfully visualized using AIM MRI. Signal enhancement was observed in the contralateral side of the primary somatosensory area (S1) and ipsilateral side cingulate areas (Cg).

Keywords

accompanies acid acquisition activation active activity administer administration agent anesthetized animals artery barrier blood bold brain brush carotid catheter channels check chronic clinical common complaint complex concerned conditions conducting connections continuous contrast depiction detect detection development difficult disrupted distal divided dorsal drug drugs either enhanced enhancement enters examined except experiment experimental external femoral field formation function functional furthermore ganglia gases gated good hind important induced influenced informatics infusing injecting injury innocuous input integrative invasive investigation isolated japan leads ligated ligation male manganese materials matrix medical medicine minutes model modulate monitor nerve nerves neural neurons neurosurgery observation operated pain paroxysmal pathway perception placed play polyethylene pressure previously primary procedure processing rapidly rats receive repetition reported role root sample sciatic segmental separation sham side slice slices sole solution spin spinal spontaneous stimulation stimuli stimulus successfully suggest supports surgery sutures system tissue treatment triggered typical underwent useful usually various vein view visualized voltage weeks