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Abstract #0942

Precise Correlation of Relative Cerebral Blood Volume & Von Willebrand Factor Stained Histology Using the HistToMRI Toolbox

Peter S. LaViolette1, Andrew C. Discolo1, Kimberly A. Pechman2, Kathleen M. Schmainda, 13

1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 2Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 3Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

We have developed a technique to precisely quantify and compare histology to MRI on a voxel-wise basis. We demonstrate its utility in a U87 rat brain tumor model, where we compare relative cerebral blood volume (rCBV) as measured with dynamic susceptibility contrast (DSC) MRI to ex vivo von Willebrand factor (vWF) expression.

Keywords

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