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Abstract #0939

Increased Astroglial Metabolism During Postnatal Development in Rat Brain

Puneet Bagga1, Anant Bahadur Patel1

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

There is a rapid increase in the number of neurons and synapse formation in the brain during postnatal development with glutamatergic and GABAergic neurons undergoing large increases in neurotransmitter cycling and oxidative energy metabolism. Whereas, no or little information is available for astroglial activity during this period. Male SD rats were studied at P10 and P30 by infusing [2-13C]acetate and 1H-[13C]-NMR Spectroscopy. In addition to remarkable neurochemical changes, acetate utilization was found to be increased by three folds at P30 indicating increased astroglial activity during postnatal period.

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Keywords

acetate acid acids activity ages amino anesthetized animal approved available best biochemistry biology brain cells cellular central cerebral committee concentration cortex cortical council critical cycling development energy enrichment ethics evaluate experiment exponential extract extracted femoral fitting folds formation frozen function funding glutamate growth hence indicated indicates industrial infused infusion institute knowledge labeling least liquid little major male materials measured metabolic metabolism metabolites molecular mono natl nervous neuronal neurons neurotransmitter nonlinear objective oxidative percent period plasma postnatal protocols rapid rats reduced regarding reporting rodents role scientific significantly situ spectra spectrometer spectroscopy spectrum spurt squares steady studied studies supported synapse system tail third tissue together undergo urethane utilization vein week