Meeting Banner
Abstract #0891

Mapping of Oxygen by Imaging Lipids Relaxation Enhancement (MOBILE): Application in a Murine Stroke Model.

Julie Magat1, Caroline Vandeputte2, Uwe Himmelreich2, Bndicte F. Jordan1, Bernard Gallez1

1Biomedical Magnetic Resonance Group, Universit Catholique de Louvain, Brussels, Belgium; 2Biomedical Nuclear - Magnetic - Resonance Unit, Katholieke Universiteit Leuven, Leuven, Belgium

Imaging brain tissue oxygenation shortly after an acute ischemic stroke may help to aid in the selection of patients who may still benefit from thrombolytic treatment beyond conventional time-based guidelines. There is a critical need for methods able to monitor dynamically and noninvasively brain oxygenation. The aim of the current work was to implement the MOBILE technique, a method developed to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids by exploiting the higher solubility property of oxygen in lipids than in water (5), in a mouse stroke model.

Keywords

able acquisition acts acute advanced agent anatomical application applications assessed bandwidth basal benefit beyond biomedical blood bold brain breathing capacity challenge coil comparing complementary contrarily contrast control critical cutoff dependent determine developed diameter dissolved dynamically early echoes enhancement equal evaluated event experiment exploiting explore fast focus frequency gradient guidelines help hemisphere hemispheres hertz highly hour identify implement indeed influenced injection inner insulted intact inversion knowing length lesion limitations lipid lipids literature longitudinal mapping maps matched material matrix mice mobile mode model monitor mostly mouse need nuclear objectives offset offsets oxygen oxygenation paramagnetic parametric patients peaks perfusion phys pixels potential potentially precession properties property protocol pulse quadrature quantify recovery respond responding response rose saturation segmented segments select selection sensitive sensitivity shortening shortly slice solubility spacing spectrum spoiled steady still stroke support tail tissue tool tools transversal treated treatment typical unilateral unit useful valuable variations vein versus vessels volume water whereas window