Meeting Banner
Abstract #0875

Probabilistic MR Atlases of Biological and Interventional Phenotypes in Human Gliomas

Benjamin M. Ellingson1, Timothy F. Cloughesy2, Whitney B. Pope1, Taryar M. Zaw1, Phioanh L. Nghiemphu2, Kourosh M. Naeini1, Robert J. Harris1, Albert Lai2

1Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States; 2Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

Studies support tumor location as playing an important role in prognosis, likely due to the genetic profile of tumor precursor cells and the stage in the development cycle that these cells transform (i.e. the glioma cell of origin). However, identifying such glioma cells of origin is still a major issue challenging the field of neuro-oncology. In the current study we have constructed probabilistic atlases specifying the most frequent tumor locations on MR for more than 400 patients. These atlases were stratified by different biological and interventional phenotypes to provide new insight into niche locations of specific glioma cells of origin.

Abstract PDF

Keywords

adjacent aggressive aligned appear approximately atlas atlases available biological board brain cancer cell cells challenging characteristics common confirmed consent consistent contact contoured contrast correlation criteria cure cycle deletion development develops discovered distinct divided enhancing enrolled examining examples expression fact favorable field fine flair form frequency frontal gene genes genetic genome germinal grade highest histology human hypothesis identified identifying importance inherent insight institutional involvement lesions likely link lobe localization located location locations medicine methylated mutant mutation natl near necrosis neural neurology niche occur occurred occurrence oncology operative origin overall overlap part patient patients phenotype phenotypes phys plausible pope post posterior power precursor predestined predominant preferentially previous probabilistic profile profiles prognostic promoter proposed radiological recently review rise role scale school sciences sets signature signed similarly source specifying stage status stem still stratified studies subclass subtype suggesting suggestive support surgical survival temporal tend tended transform treatment tumor tumors type useful whereas white wild zone