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Abstract #0869

Assessment of Intratumoral Susceptibility Signals (ITSS) in Patients with Newly Diagnosed Glioblastoma Using Quantitative Susceptibility Mapping (QSM)

Andreas Deistung1, Ferdinand Schweser1, Sabine Heiland2, Martin Bendszus2, Wolfgang Wick3, Jrgen Rainer Reichenbach1, Alexander Radbruch2

1Medical Physics Group, Department of Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Germany; 2Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany; 3Department of Neurooncology, University of Heidelberg Medical Center, Heidelberg, Germany

On susceptibility weighted images glioblastoma usually exhibit a large amount of intratumoral susceptibility signals (ITSS), enabling differentiation from other enhancing brain lesions. However, it is still unknown if these ITS signals correspond to calcium or blood deposits. Therefore, this contribution assesses ITSS in glioblastoma with quantitative susceptibility maps to differentiate between calcium or blood deposits. ITSS were classified as 80-100% hyperintense in 8 of 9 glioblastoma whereas only one of 9 glioblastoma was classified as 60-80% hyperintense, indicating that ITSS in glioblastoma originate from blood products. These findings may improve the understanding of the pathophysiology of glioblastoma.

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