Meeting Banner
Abstract #0863

Quantitative Measurements of Permeability & Blood Volume in Meningiomas Using Dynamic Susceptibility Contrast-Enhanced Perfusion Imaging

Sumei Wang1, Ronald L. Wolf1, Edward B. Lee2, Harish Poptani1, Elias R. Melhem1, John YK Lee3, Sungheon Kim4

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States; 3Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States; 4Radiology, New York University School of Medicine, New York, NY, United States

The purpose of this study is to determine whether permeability and rCBV measurements can help in determining the histologic grade and subtypes of meningiomas. Thirty-one meningiomas underwent DSC studies. All the perfusion parameters including corrected rCBV, uncorrected rCBV, Ktrans, Ve and Vp were measured from the enhancing part of the tumor. Our result showed that corrected rCBV is helpful in differentiating atypical from typical meningiomas, whereas Ktrans and Ve measurements are useful in distinguishing different subtypes of meningiomas.

Abstract PDF

Keywords

aggressive aids array atypical barrier behavior blood bolus brain capillaries cerebral channel characterization coil compositions computed constant contrast corrected correction covering determine determining diagnosis differentiating dose dynamic earlier elevated enhanced enhancing expressed extracellular flair flow grade grades gradient grading greatest head help helpful histological important included inconsistent indicates injection john laboratory lack leakage limited lowest maps materials measured medicine modeling morbidity mortality much neurosurgery overlaid pass pathology patients perfusion permeability planar planning plasma possibly preoperative previous problematic quantitative radiology recurrence registered remains report reported representative resection resolution scanner school significantly slices space statistically student studies subtype subtypes suggested surgeon surgery susceptibility table thirty together transfer transitional trio tumors typical uncorrected underwent unpaired vascular volume whether widely wolf yang