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Abstract #0854

11C-Methionine PET Parametric Response Map, But Not Conventional MRI, Corresponds to Treatment Response of WT1 Immunotherapy for Recurrent Malignant Glioma.

Manabu Kinoshita1, Yasuyoshi Chiba1, Akihiko Tsuboi2, Naoki Kagawa1, Jun Hatazawa3, Haruo Sugiyama4, Naoya Hashimoto1, Toshiki Yoshimine1

1Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Cancer Immunotherapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 3Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 4Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Immunotherapy targeting the Wilms tumor 1 (WT1) gene product is a promising treatment modality for patients with malignant gliomas with reports of encouraging results. It has become clear, however, that Gd-enhanced MRI (Gd-MRI) does not reflect prognosis, thereby necessitating a more robust imaging evaluation system for monitoring WT1 immunotherapy. In order to meet this demand, we have performed a voxel-wise parametric response map (PRM) analysis of 11C-methionine PET (Met-PET) in WT1 immunotherapy and compared the data with the overall survival after WT1 immunotherapy initiation (OSWT1). This study describes the limited value of Gd-MRI and highlights the potential of voxel-wise PRM analysis of Met-PET for monitoring treatment response in immunotherapy for malignant gliomas.

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