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Abstract #0842

Evaluation of a New Multimodality Voxel-Based Imaging Biomarker for Therapeutic Response Assessment in GBM

Benjamin Lemasson1, Thomas Chenevert1, Theodore Lawrence2, Christina Tsien2, Pia Sundgren3, Charles Meyer1, 4, Larry Junck5, Jennifer Boes1, Jean-Christophe Brisset1, Stefanie Galbn2, Timothy Johnson6, Alnawaz Rehemtulla1, Brian Ross1, Craig Galbn1

1Radiology, University of Michigan, Ann Arbor, MI, United States; 2Radiation Oncology, University of Michigan, Ann Arbor, MI, United States; 3Radiology, University of Michigan, Ann arbor, MI, United States; 4Biomedical, University of Michigan, Ann Arbor, MI, United States; 5Neurology, University of Michigan, Ann Arbor, MI, United States; 6Biostatistics, University of Michigan, Ann Arbor, MI, United States

The purpose was to evaluate the diagnostic performance of MRI based T1 and rCBV maps analyzed using a new multi-parametric response map (mPRM) base on a voxel-based analysis for early chemoradiation response prediction in patients diagnosed with high-grade gliomas. The percentage change, PRM and mPRM techniques using T1 and rCBVmap were used to assessed tumor response 1 and 3 weeks mid-treatment of 23 patients bearing glioma. mPRMT1+/rCBV- significantly identified patients resistant irrespective of tumor volume delineation and the time point mid-treatment used. This new approach could become a powerful tool to analyze multiparametric and/or multimodal data.

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Keywords

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